{"id":84076,"date":"2022-02-02T19:55:47","date_gmt":"2022-02-02T19:55:47","guid":{"rendered":"https:\/\/ergclinical.com\/?p=84076"},"modified":"2022-02-14T22:29:02","modified_gmt":"2022-02-14T22:29:02","slug":"evolution-research-group-establishes-clinical-collaborations-with-concentric-analgesics-and-the-university-of-rochester-medical-center-an-orthopedic-surgery-center-of-excellence","status":"publish","type":"post","link":"https:\/\/ergclinical.com\/es\/evolution-research-group-establishes-clinical-collaborations-with-concentric-analgesics-and-the-university-of-rochester-medical-center-an-orthopedic-surgery-center-of-excellence\/","title":{"rendered":"Evolution Research Group establece colaboraciones cl\u00ednicas con Concentric Analgesics."},"content":{"rendered":"
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Colaboraciones cl\u00ednicas establecidas con Evolution Research Group, una red de sitios de estudio del dolor posquir\u00fargico de primer nivel, y el Centro M\u00e9dico de la Universidad de Rochester, un centro de excelencia en cirug\u00eda ortop\u00e9dica<\/i><\/b><\/p>\n

Premio Nobel 2021 otorgado a cient\u00edficos que dilucidaron la importancia de TRPV1 en el dolor<\/i><\/b><\/p>\n<\/div>\n

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SAN FRANCISCO\u2013(CABLE COMERCIAL<\/a>)\u2013\u00a0Analg\u00e9sicos conc\u00e9ntricos<\/a>, Inc., una compa\u00f1\u00eda biofarmac\u00e9utica en etapa cl\u00ednica enfocada en el desarrollo y comercializaci\u00f3n de terapias novedosas para el dolor no opioides, anunci\u00f3 hoy dos importantes relaciones cl\u00ednicas de fase 3 para su principal producto candidato, vocacapsaicina.<\/p>\n

En primer lugar, la empresa ha firmado un acuerdo formal con Evolution Research Group (ERG), una red l\u00edder de sitios de investigaci\u00f3n cl\u00ednica sobre el dolor posquir\u00fargico en los EE. UU., para llevar a cabo sus ensayos de registro.<\/p>\n

\u201cTras nuestra experiencia con vocacapsaicina en los estudios de fase 2, estamos entusiasmados por la posibilidad de reproducir estos resultados de eficacia y seguridad en los estudios de fase 3\u201d, afirm\u00f3 el Dr. Harold Minkowitz, presidente de Analgesics, Perioperative & Hospital Based Research en HD Research LLC, una empresa de la cartera de Evolution Research Group. \u201cNuestros pacientes tienen una gran necesidad de opciones eficaces para el tratamiento del dolor sin opioides, y estamos muy seguros de que esto se puede lograr con vocacapsaicina\u201d.<\/p>\n

Adem\u00e1s, Concentric anunci\u00f3 una colaboraci\u00f3n multifac\u00e9tica con el Centro M\u00e9dico de la Universidad de Rochester (URMC), un centro de primera clase en la investigaci\u00f3n, desarrollo y uso de los productos y t\u00e9cnicas de cirug\u00eda ortop\u00e9dica m\u00e1s recientes. URMC participar\u00e1 en los ensayos cl\u00ednicos de fase 3 de vocacapsaicina y desarrollar\u00e1 m\u00e9todos innovadores para aprovechar los beneficios de la vocacapsaicina en la recuperaci\u00f3n y rehabilitaci\u00f3n de los pacientes.<\/p>\n

\u201cEl perfil terap\u00e9utico demostrado por la vocacapsaicina en el estudio de artroplastia total de rodilla (TKA) de Fase 2 es convincente y es ideal para la gran mayor\u00eda de las cirug\u00edas ortop\u00e9dicas\u201d, afirm\u00f3 el Dr. Michael D. Maloney, profesor decano de ortopedia, jefe de la divisi\u00f3n de Medicina Deportiva y director m\u00e9dico del Centro de Cirug\u00eda Ambulatoria de URMC. \u201cUna terapia que pueda minimizar o eliminar la necesidad de opioides en los per\u00edodos posquir\u00fargicos y de rehabilitaci\u00f3n tendr\u00eda un tremendo impacto cl\u00ednico y social. Si los beneficios cl\u00ednicos ya observados en la TKA se pueden extender a otros procedimientos ortop\u00e9dicos, la vocacapsaicina tiene el potencial de convertirse en un nuevo est\u00e1ndar de atenci\u00f3n\u201d.<\/p>\n

\u201cEstamos encantados de trabajar con estas instituciones de alto nivel mientras nos preparamos para iniciar nuestros estudios fundamentales\u201d, afirm\u00f3 Susan Kramer, doctora en salud p\u00fablica y vicepresidenta ejecutiva de desarrollo de Concentric Analgesics. \u201cLa calidad y la escala inigualables de la red de centros quir\u00fargicos de ERG, combinadas con la amplia y profunda experiencia de URMC, ser\u00e1n fundamentales para la ejecuci\u00f3n exitosa del programa de Fase 3 de vocacapsaicina\u201d.<\/p>\n

Premio Nobel 2021 otorgado a los descubridores del receptor TRPV1, el objetivo de la vocacapsaicina<\/i><\/b><\/p>\n

El Premio Nobel de Fisiolog\u00eda o Medicina 2021 fue otorgado al profesor David Julius de la UCSF y al profesor Ardem Patapoutian de Scripps Research por sus descubrimientos de los receptores de temperatura y tacto. El trabajo del profesor Julius se ha centrado en c\u00f3mo nuestros cuerpos perciben el calor, el fr\u00edo y los irritantes qu\u00edmicos, lo que ha dado lugar a nuevos conocimientos sobre la naturaleza fundamental del dolor y a nuevos objetivos para la terapia del dolor, incluido el receptor TRPV1, com\u00fanmente conocido como receptor de la "capsaicina".<\/p>\n

\u201cFelicitamos al profesor Julius y a su equipo de la UCSF por este premio y sus extraordinarias contribuciones a la ciencia y la medicina\u201d, dijo\u00a0Juan Donovan<\/a>, MD, director cient\u00edfico de Concentric Analgesics. \u201cNuestra cartera de prof\u00e1rmacos agonistas de TRPV1, incluida la vocacapsaicina, se basa en sus descubrimientos fundamentales y tiene el potencial de revolucionar el tratamiento del dolor\u201d.<\/p>\n

Acerca de la Vocacapsaicina (CA-008)<\/strong><\/p>\n

El principal candidato a producto de Concentric Analgesics para el dolor posquir\u00fargico es un prof\u00e1rmaco terap\u00e9utico patentado, el primero en su clase, que se convierte r\u00e1pidamente en capsaicina, un potente agonista de TRPV1. A diferencia de los anest\u00e9sicos locales, la capsaicina desensibiliza selectivamente las fibras nerviosas conductoras del dolor sin producir entumecimiento sensorial ni debilidad motora. La vocacapsaicina, inyectada en el sitio quir\u00fargico como una soluci\u00f3n acuosa durante la cirug\u00eda, tiene el potencial de reducir o eliminar la necesidad de opioides en el per\u00edodo de recuperaci\u00f3n posquir\u00fargica y brindar un alivio del dolor cl\u00ednicamente significativo durante dos semanas. La vocacapsaicina ha recibido la designaci\u00f3n Fast Track (2017) y la designaci\u00f3n Breakthrough Therapy (2018) de la Administraci\u00f3n de Alimentos y Medicamentos de los Estados Unidos.<\/p>\n

Acerca de la adicci\u00f3n a los opioides y el dolor posquir\u00fargico<\/strong><\/p>\n

La adicci\u00f3n a los opioides en los Estados Unidos ha alcanzado proporciones epid\u00e9micas, destruyendo familias, vidas y comunidades en todo el pa\u00eds. Seg\u00fan los Centros para el Control y la Prevenci\u00f3n de Enfermedades, aproximadamente 70.000 estadounidenses murieron por sobredosis de opioides en 2020, 66% m\u00e1s que el n\u00famero total de muertes por accidentes automovil\u00edsticos. Es imperativo implementar nuevos enfoques para prevenir esta insidiosa enfermedad, incluso en el entorno posquir\u00fargico, que puede ser una puerta de entrada inesperada al abuso de analg\u00e9sicos recetados y m\u00e1s all\u00e1. Un estudio de 2016\u00a0Noticias de EE.UU. y reportaje mundial\u00a0<\/i>Un estudio revel\u00f3 que uno de cada diez pacientes se vuelve adicto o dependiente de los opioides despu\u00e9s de una cirug\u00eda. Con m\u00e1s de 100 millones de cirug\u00edas realizadas en los EE. UU. en 2017, 30 millones de las cuales requirieron tratamiento del dolor posoperatorio con productos que no eran medicamentos de venta libre (OTC), el mandato de desarrollar alternativas seguras y efectivas sin opioides es claro.<\/p>\n

Acerca de los analg\u00e9sicos conc\u00e9ntricos<\/strong><\/p>\n

Concentric Analgesics es una empresa biofarmac\u00e9utica en fase cl\u00ednica centrada en el desarrollo y la comercializaci\u00f3n de nuevos tratamientos para el dolor sin opioides. La cartera de productos patentados de la empresa est\u00e1 dise\u00f1ada para proporcionar un tratamiento selectivo y duradero del dolor.\u00a0<\/i>alivio\u00a0<\/i>Despu\u00e9s de una \u00fanica administraci\u00f3n local, Vocacapsaicin es el principal candidato a producto de la empresa, listo para la fase 3, para el dolor posquir\u00fargico. Concentric tiene dos programas activos adicionales para el dolor por osteoartritis y el dolor cr\u00f3nico refractario. Para obtener m\u00e1s informaci\u00f3n, visite el sitio web de la empresa en:\u00a0www.analg\u00e9sicosconc\u00e9ntricos.com<\/a>.<\/p>\n

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La versi\u00f3n original de este comunicado se encuentra en businesswire.com:\u00a0<\/span>https:\/\/www.businesswire.com\/news\/home\/20220202005254\/en\/<\/a><\/span><\/p>\n<\/div>\n

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CONTACTOS<\/h2>\n<\/div>\n
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Para m\u00e1s informaci\u00f3n:<\/b>
\nFrank Bellizzi
\nDirector ejecutivo
\nAnalg\u00e9sicos Conc\u00e9ntricos, Inc.
\nfrank@concentricanalgesics.com<\/a><\/p>\n<\/div>\n<\/div>\n

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 <\/p>\n

Fuente: Concentric Analgesics, Inc.<\/p>","protected":false},"excerpt":{"rendered":"

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